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The european society of cardiology (ESC) meeting in Barcelona caused great uproar over drug-eluting stents (DESs) and the controversy persist till today.

Professor carlo Di MArio, A professor of cardiology at the royal Brompton Hospital,London,said the following the ESC 2006 meeting,Data from randomized trials and regitries and restonosis,re-intervention,latestent trhombosis,myocardial infraction (MI) and mortalilty with bare metal stents (BMSs) were intensely scrutinized.

The Data indicated ther were some important differences between the stents types,with diverse mechanical and Pharmacological properties giving rise to different clinical outcomes.

The results showed that more than 1 year after implantations,late-stent thrombosis rarely developed in patients with DESs,it occured in approxiamately 0.1 to 0.2 percents annualy in simle lesions patients randomized in clinical trials and higher in all incomers with high avergae complex interventions (0.2 to 0.6 percents).

Existing data show that this trend persist for the first 3 to 4 years after imnplantation.However,the increased rate of trhombosis does note give rise to an increase in mortality and MI in more than two third cases”Di Mario told audience in main session on DES safety.

meta-analyzes of randomized trials and some early all-comer reigistries indicate that patients using BMSs and DESs had similiar mortality and incidence of MI,with DESs reducing the need for re-interventions(Lancet 2007;369:667-78 james S,presented at the ESC congress,1-5 September 2007,Vienna,Austria).

However DI Mario notedthat there is limited data addressing the long terms safety such as diabetics and patients with complex lessions,although registry data and small greater benefits in terms of new revascularization and late events.

DESs still remaina controversial issue,said Di Mario.he further stressed the costion effectiveness analyses and careful einterpretation of specific patients subset analyses (especially as clinical trial data may not reflect real world clinical practice) are necessary to define DES indications

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