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Posts Tagged ‘COPD’

The combination of inhaled steroids with long-acting beta-2-agonists (fluticasone + salmeterol;seretide)has been demonstrated to achieve a42 percent reduction in the rate of exacerbations requiring oralcorticosteroids, as compared to placebo (p<0.001) (figure 2).

in addition, combination therapy reduces several’s inflammatory cells and cytokines with a resultant decrease in the inflammation associated with COPD. Read the rest of this entry »

Inflammation COPD is characterised by the presence of CD+8 T-cells and macrophages in bronchial biopsies and an abundance of neutrophils in sputum. these tissue findings are contrast to asthma,where eosinophils are the dominant cell types.
interestingly,during exacerbations of mild COPD,a change in airway inflammation has been reported with increase in sputum eosinophuls. the rise in sputum eosinophils has been attributed to an increase in the expression. the benefits of steroid therapy during COPD exacerbation  can be explained by its impact on RANTES,a steroid sensitive eosinophils cytokine. Read the rest of this entry »

COPD is characterized by inflammation at all stages of desease severity correlating with various measures of inflammation plays underlying role in pathologies of a number of extrapulmonary effects and co-morbidities associated with COPD.The synergistic effects of fluticasone and salmaterol combination,results in significiant anti-inflammatory effects in COPD.which are not seen with in haled corticosteroids alone
These anti-inflammatory effects are likely to contribute to the observed clinical benefits of inhaled corticosteroids and long-acting beta-2-agonists combination in COPD.