Posts Tagged ‘anti-inflammatory’

Impact of anti-inflammatory agents

The combination of inhaled steroids with long-acting beta-2-agonists (fluticasone + salmeterol;seretide)has been demonstrated to achieve a42 percent reduction in the rate of exacerbations requiring oralcorticosteroids, as compared to placebo (p<0.001) (figure 2).

in addition, combination therapy reduces several’s inflammatory cells and cytokines with a resultant decrease in the inflammation associated with COPD. Read the rest of this entry »

Inflammatory response correlates with COPD progression and contributes to the clinical benefits of ICS/laba combination therapy

COPD is characterized by inflammation at all stages of desease severity correlating with various measures of inflammation plays underlying role in pathologies of a number of extrapulmonary effects and co-morbidities associated with COPD.The synergistic effects of fluticasone and salmaterol combination,results in significiant anti-inflammatory effects in COPD.which are not seen with in haled corticosteroids alone
These anti-inflammatory effects are likely to contribute to the observed clinical benefits of inhaled corticosteroids and long-acting beta-2-agonists combination in COPD.